Species-Specific and Inhibitor-Dependent Conformations of LpxC—Implications for Antibiotic Design

LpxC is an essential enzyme in the lipid A biosynthetic pathway in Gram-negative bacteria. Several promising antimicrobial lead compounds targeting LpxC have been reported, though they typically display a large variation in potency against different Gram-negative pathogens. We report that inhibitors...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Lee, Chul-Jin, Liang, Xiaofei, Chen, Xin, Zeng, Daina, Joo, Sang Hoon, Chung, Hak Suk, Barb, Adam W., Swanson, Shauna M., Nicholas, Robert A., Li, Yaoxian, Toone, Eric J., Raetz, Christian R. H., Zhou, Pei
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149848/
https://ncbi.nlm.nih.gov/pubmed/21167751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.11.011
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires