Species-Specific and Inhibitor-Dependent Conformations of LpxC—Implications for Antibiotic Design

LpxC is an essential enzyme in the lipid A biosynthetic pathway in Gram-negative bacteria. Several promising antimicrobial lead compounds targeting LpxC have been reported, though they typically display a large variation in potency against different Gram-negative pathogens. We report that inhibitors...

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Detalhes bibliográficos
Main Authors: Lee, Chul-Jin, Liang, Xiaofei, Chen, Xin, Zeng, Daina, Joo, Sang Hoon, Chung, Hak Suk, Barb, Adam W., Swanson, Shauna M., Nicholas, Robert A., Li, Yaoxian, Toone, Eric J., Raetz, Christian R. H., Zhou, Pei
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149848/
https://ncbi.nlm.nih.gov/pubmed/21167751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.11.011
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