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Uridine-based inhibitors as new leads for antibiotics targeting E. coli LpxC
The UDP-3-O-(R-3-hydroxyacyl)-N-acetylglucosamine deacetylase LpxC catalyzes the committed reaction of lipid A (endotoxin) biosynthesis in Gram-negative bacteria and is a validated antibiotic target. Although several previously described compounds bind to the unique acyl chain binding passage of Lpx...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2709817/ https://ncbi.nlm.nih.gov/pubmed/19256534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900167q |
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