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Species-Specific and Inhibitor-Dependent Conformations of LpxC—Implications for Antibiotic Design
LpxC is an essential enzyme in the lipid A biosynthetic pathway in Gram-negative bacteria. Several promising antimicrobial lead compounds targeting LpxC have been reported, though they typically display a large variation in potency against different Gram-negative pathogens. We report that inhibitors...
में बचाया:
| मुख्य लेखकों: | , , , , , , , , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2010
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3149848/ https://ncbi.nlm.nih.gov/pubmed/21167751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.11.011 |
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