Potent LpxC Inhibitors with In Vitro Activity against Multidrug-Resistant Pseudomonas aeruginosa

New drugs with novel mechanisms of resistance are desperately needed to address both community and nosocomial infections due to Gram-negative bacteria. One such potential target is LpxC, an essential enzyme that catalyzes the first committed step of lipid A biosynthesis. Achaogen conducted an extens...

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Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Krause, Kevin M., Haglund, Cat M., Hebner, Christy, Serio, Alisa W., Lee, Grace, Nieto, Vincent, Cohen, Frederick, Kane, Timothy R., Machajewski, Timothy D., Hildebrandt, Darrin, Pillar, Chris, Thwaites, Mary, Hall, Danielle, Miesel, Lynn, Hackel, Meredith, Burek, Amanda, Andrews, Logan D., Armstrong, Eliana, Swem, Lee, Jubb, Adrian, Cirz, Ryan T.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2019
Sujets:
Susceptibility
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6811409/
https://ncbi.nlm.nih.gov/pubmed/31451507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00977-19
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