Potent LpxC Inhibitors with In Vitro Activity against Multidrug-Resistant Pseudomonas aeruginosa

New drugs with novel mechanisms of resistance are desperately needed to address both community and nosocomial infections due to Gram-negative bacteria. One such potential target is LpxC, an essential enzyme that catalyzes the first committed step of lipid A biosynthesis. Achaogen conducted an extens...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Krause, Kevin M., Haglund, Cat M., Hebner, Christy, Serio, Alisa W., Lee, Grace, Nieto, Vincent, Cohen, Frederick, Kane, Timothy R., Machajewski, Timothy D., Hildebrandt, Darrin, Pillar, Chris, Thwaites, Mary, Hall, Danielle, Miesel, Lynn, Hackel, Meredith, Burek, Amanda, Andrews, Logan D., Armstrong, Eliana, Swem, Lee, Jubb, Adrian, Cirz, Ryan T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Susceptibility
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6811409/
https://ncbi.nlm.nih.gov/pubmed/31451507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00977-19
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