Potent LpxC Inhibitors with In Vitro Activity against Multidrug-Resistant Pseudomonas aeruginosa

New drugs with novel mechanisms of resistance are desperately needed to address both community and nosocomial infections due to Gram-negative bacteria. One such potential target is LpxC, an essential enzyme that catalyzes the first committed step of lipid A biosynthesis. Achaogen conducted an extens...

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Библиографические подробности
Опубликовано в: :Antimicrob Agents Chemother
Главные авторы: Krause, Kevin M., Haglund, Cat M., Hebner, Christy, Serio, Alisa W., Lee, Grace, Nieto, Vincent, Cohen, Frederick, Kane, Timothy R., Machajewski, Timothy D., Hildebrandt, Darrin, Pillar, Chris, Thwaites, Mary, Hall, Danielle, Miesel, Lynn, Hackel, Meredith, Burek, Amanda, Andrews, Logan D., Armstrong, Eliana, Swem, Lee, Jubb, Adrian, Cirz, Ryan T.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2019
Предметы:
Susceptibility
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6811409/
https://ncbi.nlm.nih.gov/pubmed/31451507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00977-19
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