Potent LpxC Inhibitors with In Vitro Activity against Multidrug-Resistant Pseudomonas aeruginosa

New drugs with novel mechanisms of resistance are desperately needed to address both community and nosocomial infections due to Gram-negative bacteria. One such potential target is LpxC, an essential enzyme that catalyzes the first committed step of lipid A biosynthesis. Achaogen conducted an extens...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Antimicrob Agents Chemother
Prif Awduron: Krause, Kevin M., Haglund, Cat M., Hebner, Christy, Serio, Alisa W., Lee, Grace, Nieto, Vincent, Cohen, Frederick, Kane, Timothy R., Machajewski, Timothy D., Hildebrandt, Darrin, Pillar, Chris, Thwaites, Mary, Hall, Danielle, Miesel, Lynn, Hackel, Meredith, Burek, Amanda, Andrews, Logan D., Armstrong, Eliana, Swem, Lee, Jubb, Adrian, Cirz, Ryan T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2019
Pynciau:
Susceptibility
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6811409/
https://ncbi.nlm.nih.gov/pubmed/31451507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00977-19
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