Potent LpxC Inhibitors with In Vitro Activity against Multidrug-Resistant Pseudomonas aeruginosa

New drugs with novel mechanisms of resistance are desperately needed to address both community and nosocomial infections due to Gram-negative bacteria. One such potential target is LpxC, an essential enzyme that catalyzes the first committed step of lipid A biosynthesis. Achaogen conducted an extens...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Krause, Kevin M., Haglund, Cat M., Hebner, Christy, Serio, Alisa W., Lee, Grace, Nieto, Vincent, Cohen, Frederick, Kane, Timothy R., Machajewski, Timothy D., Hildebrandt, Darrin, Pillar, Chris, Thwaites, Mary, Hall, Danielle, Miesel, Lynn, Hackel, Meredith, Burek, Amanda, Andrews, Logan D., Armstrong, Eliana, Swem, Lee, Jubb, Adrian, Cirz, Ryan T.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2019
Témata:
Susceptibility
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6811409/
https://ncbi.nlm.nih.gov/pubmed/31451507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00977-19
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