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Mutations Reducing In Vitro Susceptibility to Novel LpxC Inhibitors in Pseudomonas aeruginosa and Interplay of Efflux and Nonefflux Mechanisms
Upregulated expression of efflux pumps, lpxC target mutations, LpxC protein overexpression, and mutations in fabG were previously shown to mediate single-step resistance to the LpxC inhibitor CHIR-090 in P. aeruginosa. Single-step selection experiments using three recently described LpxC inhibitors...
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| 出版年: | Antimicrob Agents Chemother |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Microbiology
2019
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7187589/ https://ncbi.nlm.nih.gov/pubmed/31658970 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01490-19 |
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