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Phosphorylation of Histone Deacetylase 8: Structural and Mechanistic Analysis of Phosphomimetic S39E Mutant
Histone deacetylase (HDAC) enzymes that catalyze removal of acetyl-lysine post translational modifications are frequently post-translationally modified. HDAC8 is phosphorylated within the deacetylase domain at conserved residue serine 39 which leads to decreased catalytic activity. HDAC8 phosphoryla...
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| Pubblicato in: | Biochemistry |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6903415/ https://ncbi.nlm.nih.gov/pubmed/31633931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00653 |
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