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Phosphorylation of Histone Deacetylase 8: Structural and Mechanistic Analysis of Phosphomimetic S39E Mutant

Histone deacetylase (HDAC) enzymes that catalyze removal of acetyl-lysine post translational modifications are frequently post-translationally modified. HDAC8 is phosphorylated within the deacetylase domain at conserved residue serine 39 which leads to decreased catalytic activity. HDAC8 phosphoryla...

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Vydáno v:Biochemistry
Hlavní autoři: Leng, Katherine R. Welker, Castañeda, Carol Ann, Decroos, Christophe, Islam, Barira, Haider, Shozeb M., Christianson, David W., Fierke, Carol A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6903415/
https://ncbi.nlm.nih.gov/pubmed/31633931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00653
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