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On the Function of the Internal Cavity of Histone Deacetylase Protein 8: R37 is a Crucial Residue for Catalysis
Biochemical studies reveal that a conserved arginine residue (R37) at the centre of the 14 Å internal cavity of histone deacetylase (HDAC) 8 is important for catalysis and acetate affinity. Computational studies indicate that R37 forms multiple hydrogen bonding interactions with the backbone carbony...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3286521/ https://ncbi.nlm.nih.gov/pubmed/21320778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.01.128 |
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