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General Base-General Acid Catalysis in Human Histone Deacetylase 8
Histone deacetylases (HDACs) regulate cellular processes such as differentiation and apoptosis, and are targeted by anti-cancer therapeutics in development and in the clinic. HDAC8 is a metal-dependent class I HDAC and is proposed to use a general acid-base catalytic pair in the mechanism of amide b...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4747815/ https://ncbi.nlm.nih.gov/pubmed/26806311 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01327 |
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