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General Base-General Acid Catalysis in Human Histone Deacetylase 8

Histone deacetylases (HDACs) regulate cellular processes such as differentiation and apoptosis, and are targeted by anti-cancer therapeutics in development and in the clinic. HDAC8 is a metal-dependent class I HDAC and is proposed to use a general acid-base catalytic pair in the mechanism of amide b...

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Bibliografische gegevens
Gepubliceerd in:Biochemistry
Hoofdauteurs: Lucy Gantt, Sister M., Decroos, Christophe, Lee, Matthew S., Gullett, Laura E., Bowman, Christine M., Christianson, David W., Fierke, Carol A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747815/
https://ncbi.nlm.nih.gov/pubmed/26806311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01327
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