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Structural and Functional Influence of the Glycine-Rich Loop G(302)GGGY on the Catalytic Tyrosine of Histone Deacetylase 8
Histone deacetylase 8 (HDAC8) catalyzes the hydrolysis of acetyl-L-lysine to yield products L-lysine and acetate through a mechanism in which a nucleophilic water molecule is activated by a histidine general base and a catalytic metal ion (Zn(2+) or Fe(2+)). Acetyl-L-lysine also requires activation...
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| Veröffentlicht in: | Biochemistry |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5161102/ https://ncbi.nlm.nih.gov/pubmed/27933794 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01014 |
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