Structures of Metal-Substituted Human Histone Deacetylase 8 Provide Mechanistic Inferences on Biological Function,

The metal-dependent histone deacetylases (HDACs) adopt an α/β protein fold first identified in rat liver arginase. Despite insignificant overall amino acid sequence identity, these enzymes share a strictly conserved metal-binding site with divergent metal specificity and stoichiometry. HDAC8, origin...

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Hauptverfasser: Dowling, Daniel P., Gattis, Samuel G., Fierke, Carol A., Christianson, David W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895166/
https://ncbi.nlm.nih.gov/pubmed/20545365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1005046
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