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Mechanistic Inferences from the Binding of Ligands to LpxC, a Metal-Dependent Deacetylase(,)
The metal-dependent deacetylase LpxC catalyzes the first committed step of lipid A biosynthesis in Gram-negative bacteria. Accordingly, LpxC is an attractive target for the development of inhibitors that may serve as potential new antibiotics for the treatment of Gram-negative bacterial infections....
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2006
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2505344/ https://ncbi.nlm.nih.gov/pubmed/16800620 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi060823m |
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