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Binding of Uridine 5′-Diphosphate in the “Basic Patch” of the Zinc Deacetylase LpxC and Implications for Substrate Binding

LpxC is a zinc metalloenzyme that catalyzes the first committed step in the biosynthesis of lipid A, a vital component of the outer membrane of Gram-negative bacteria. Accordingly, the inhibition of LpxC is an attractive strategy for the treatment of Gram-negative bacterial infections. Here, we repo...

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Detalhes bibliográficos
Main Authors: Gennadios, Heather A., Christianson, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527469/
https://ncbi.nlm.nih.gov/pubmed/17176043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi0619021
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