Molecular Validation of LpxC as an Antibacterial Drug Target in Pseudomonas aeruginosa

LpxC [UDP-3-O-(R-3-hydroxymyristoyl)-GlcNAc deacetylase] is a metalloamidase that catalyzes the first committed step in the biosynthesis of the lipid A component of lipopolysaccharide. A previous study (H. R. Onishi, B. A. Pelak, L. S. Gerckens, L. L. Silver, F. M. Kahan, M. H. Chen, A. A. Patchett,...

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Detalles Bibliográficos
Autores principales: Mdluli, Khisimuzi E., Witte, Pamela R., Kline, Toni, Barb, Adam W., Erwin, Alice L., Mansfield, Bryce E., McClerren, Amanda L., Pirrung, Michael C., Tumey, L. Nathan, Warrener, Paul, Raetz, Christian R. H., Stover, C. Kendall
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2006
Materias:
Mechanisms of Action: Physiological Effects
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1479155/
https://ncbi.nlm.nih.gov/pubmed/16723580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00140-06
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