Molecular Validation of LpxC as an Antibacterial Drug Target in Pseudomonas aeruginosa

LpxC [UDP-3-O-(R-3-hydroxymyristoyl)-GlcNAc deacetylase] is a metalloamidase that catalyzes the first committed step in the biosynthesis of the lipid A component of lipopolysaccharide. A previous study (H. R. Onishi, B. A. Pelak, L. S. Gerckens, L. L. Silver, F. M. Kahan, M. H. Chen, A. A. Patchett,...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Mdluli, Khisimuzi E., Witte, Pamela R., Kline, Toni, Barb, Adam W., Erwin, Alice L., Mansfield, Bryce E., McClerren, Amanda L., Pirrung, Michael C., Tumey, L. Nathan, Warrener, Paul, Raetz, Christian R. H., Stover, C. Kendall
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2006
Pynciau:
Mechanisms of Action: Physiological Effects
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1479155/
https://ncbi.nlm.nih.gov/pubmed/16723580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00140-06
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