Molecular Validation of LpxC as an Antibacterial Drug Target in Pseudomonas aeruginosa

LpxC [UDP-3-O-(R-3-hydroxymyristoyl)-GlcNAc deacetylase] is a metalloamidase that catalyzes the first committed step in the biosynthesis of the lipid A component of lipopolysaccharide. A previous study (H. R. Onishi, B. A. Pelak, L. S. Gerckens, L. L. Silver, F. M. Kahan, M. H. Chen, A. A. Patchett,...

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Bibliografski detalji
Glavni autori: Mdluli, Khisimuzi E., Witte, Pamela R., Kline, Toni, Barb, Adam W., Erwin, Alice L., Mansfield, Bryce E., McClerren, Amanda L., Pirrung, Michael C., Tumey, L. Nathan, Warrener, Paul, Raetz, Christian R. H., Stover, C. Kendall
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2006
Teme:
Mechanisms of Action: Physiological Effects
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1479155/
https://ncbi.nlm.nih.gov/pubmed/16723580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00140-06
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