Single-molecule level structural dynamics of DNA unwinding by human mitochondrial Twinkle helicase

Knowledge of the molecular events in mitochondrial DNA (mtDNA) replication is crucial to understanding the origins of human disorders arising from mitochondrial dysfunction. Twinkle helicase is an essential component of mtDNA replication. Here, we employed atomic force microscopy imaging in air and...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Kaur, Parminder, Longley, Matthew J., Pan, Hai, Wang, Wendy, Countryman, Preston, Wang, Hong, Copeland, William C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2020
Schlagworte:
DNA and Chromosomes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7186178/
https://ncbi.nlm.nih.gov/pubmed/32213598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012795
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