Single-molecule level structural dynamics of DNA unwinding by human mitochondrial Twinkle helicase

Knowledge of the molecular events in mitochondrial DNA (mtDNA) replication is crucial to understanding the origins of human disorders arising from mitochondrial dysfunction. Twinkle helicase is an essential component of mtDNA replication. Here, we employed atomic force microscopy imaging in air and...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Kaur, Parminder, Longley, Matthew J., Pan, Hai, Wang, Wendy, Countryman, Preston, Wang, Hong, Copeland, William C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2020
Fag:
DNA and Chromosomes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7186178/
https://ncbi.nlm.nih.gov/pubmed/32213598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012795
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