Biochemical Characterization of the Human Mitochondrial Replicative Twinkle Helicase: SUBSTRATE SPECIFICITY, DNA BRANCH MIGRATION, AND ABILITY TO OVERCOME BLOCKADES TO DNA UNWINDING

Mutations in the c10orf2 gene encoding the human mitochondrial DNA replicative helicase Twinkle are linked to several rare genetic diseases characterized by mitochondrial defects. In this study, we have examined the catalytic activity of Twinkle helicase on model replication fork and DNA repair stru...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Khan, Irfan, Crouch, Jack D., Bharti, Sanjay Kumar, Sommers, Joshua A., Carney, Sean M., Yakubovskaya, Elena, Garcia-Diaz, Miguel, Trakselis, Michael A., Brosh, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933186/
https://ncbi.nlm.nih.gov/pubmed/27226550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.712026
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