Biochemical Characterization of the Human Mitochondrial Replicative Twinkle Helicase: SUBSTRATE SPECIFICITY, DNA BRANCH MIGRATION, AND ABILITY TO OVERCOME BLOCKADES TO DNA UNWINDING

Mutations in the c10orf2 gene encoding the human mitochondrial DNA replicative helicase Twinkle are linked to several rare genetic diseases characterized by mitochondrial defects. In this study, we have examined the catalytic activity of Twinkle helicase on model replication fork and DNA repair stru...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Khan, Irfan, Crouch, Jack D., Bharti, Sanjay Kumar, Sommers, Joshua A., Carney, Sean M., Yakubovskaya, Elena, Garcia-Diaz, Miguel, Trakselis, Michael A., Brosh, Robert M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2016
Onderwerpen:
DNA and Chromosomes
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933186/
https://ncbi.nlm.nih.gov/pubmed/27226550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.712026
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