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Polymerase θ-helicase efficiently unwinds DNA and RNA-DNA hybrids

POLQ is a unique multifunctional replication and repair gene that encodes for a N-terminal superfamily 2 helicase and a C-terminal A-family polymerase. Although the function of the polymerase domain has been investigated, little is understood regarding the helicase domain. Multiple studies have repo...

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Foilsithe in:J Biol Chem
Main Authors: Ozdemir, Ahmet Y., Rusanov, Timur, Kent, Tatiana, Siddique, Labiba A., Pomerantz, Richard T.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5892577/
https://ncbi.nlm.nih.gov/pubmed/29444826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000565
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