DNA polymerase θ specializes in incorporating synthetic expanded-size (xDNA) nucleotides

DNA polymerase θ (Polθ) is a unique A-family polymerase that is essential for alternative end-joining (alt-EJ) of double-strand breaks (DSBs) and performs translesion synthesis. Because Polθ is highly expressed in cancer cells, confers resistance to ionizing radiation and chemotherapy agents, and pr...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Kent, Tatiana, Rusanov, Timur D., Hoang, Trung M., Velema, Willem A., Krueger, Andrew T., Copeland, William C., Kool, Eric T., Pomerantz, Richard T.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5100566/
https://ncbi.nlm.nih.gov/pubmed/27591252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw721
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