Polθ reverse transcribes RNA and promotes RNA-templated DNA repair

Genome-embedded ribonucleotides arrest replicative DNA polymerases (Pols) and cause DNA breaks. Whether mammalian DNA repair Pols efficiently use template ribonucleotides and promote RNA-templated DNA repair synthesis remains unknown. We find that human Polθ reverse transcribes RNA, similar to retro...

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Bibliografske podrobnosti
izdano v:Sci Adv
Main Authors: Chandramouly, Gurushankar, Zhao, Jiemin, McDevitt, Shane, Rusanov, Timur, Hoang, Trung, Borisonnik, Nikita, Treddinick, Taylor, Lopezcolorado, Felicia Wednesday, Kent, Tatiana, Siddique, Labiba A., Mallon, Joseph, Huhn, Jacklyn, Shoda, Zainab, Kashkina, Ekaterina, Brambati, Alessandra, Stark, Jeremy M., Chen, Xiaojiang S., Pomerantz, Richard T.
Format: Artigo
Jezik:Inglês
Izdano: American Association for the Advancement of Science 2021
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8195485/
https://ncbi.nlm.nih.gov/pubmed/34117057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abf1771
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