Molecular basis of microhomology-mediated end-joining by purified full-length Polθ

DNA polymerase θ (Polθ) is a unique polymerase-helicase fusion protein that promotes microhomology-mediated end-joining (MMEJ) of DNA double-strand breaks (DSBs). How full-length human Polθ performs MMEJ at the molecular level remains unknown. Using a biochemical approach, we find that the helicase...

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Published in:Nat Commun
Main Authors: Black, Samuel J., Ozdemir, Ahmet Y., Kashkina, Ekaterina, Kent, Tatiana, Rusanov, Timur, Ristic, Dejan, Shin, Yeonoh, Suma, Antonio, Hoang, Trung, Chandramouly, Gurushankar, Siddique, Labiba A., Borisonnik, Nikita, Sullivan-Reed, Katherine, Mallon, Joseph S., Skorski, Tomasz, Carnevale, Vincenzo, Murakami, Katsuhiko S., Wyman, Claire, Pomerantz, Richard T.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764996/
https://ncbi.nlm.nih.gov/pubmed/31562312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12272-9
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