Mechanism of Microhomology-Mediated End-Joining Promoted by Human DNA Polymerase Theta

Microhomology-mediated end-joining (MMEJ) is an error-prone alternative double-strand break repair pathway that utilizes sequence microhomology to recombine broken DNA. Although MMEJ is implicated in cancer development, the mechanism of this pathway is unknown. We demonstrate that purified human DNA...

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Bibliografske podrobnosti
izdano v:Nat Struct Mol Biol
Main Authors: Kent, Tatiana, Chandramouly, Gurushankar, McDevitt, Shane Michael, Ozdemir, Ahmet Y., Pomerantz, Richard T.
Format: Artigo
Jezik:Inglês
Izdano: 2015
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351179/
https://ncbi.nlm.nih.gov/pubmed/25643323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2961
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