Mechanism of Microhomology-Mediated End-Joining Promoted by Human DNA Polymerase Theta

Microhomology-mediated end-joining (MMEJ) is an error-prone alternative double-strand break repair pathway that utilizes sequence microhomology to recombine broken DNA. Although MMEJ is implicated in cancer development, the mechanism of this pathway is unknown. We demonstrate that purified human DNA...

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Bibliographic Details
Published in:Nat Struct Mol Biol
Main Authors: Kent, Tatiana, Chandramouly, Gurushankar, McDevitt, Shane Michael, Ozdemir, Ahmet Y., Pomerantz, Richard T.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351179/
https://ncbi.nlm.nih.gov/pubmed/25643323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2961
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