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Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway

DNA polymerase theta (Polθ) has been identified as a crucial alternative non-homologous end-joining factor in mammalian cells. Polθ is upregulated in a range of cancer cell types defective in homologous recombination, and knockdown has been shown to inhibit cell survival in a subset of these, making...

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Publicat a:Structure
Autors principals: Newman, Joseph A., Cooper, Christopher D.O., Aitkenhead, Hazel, Gileadi, Opher
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4671958/
https://ncbi.nlm.nih.gov/pubmed/26636256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.10.014
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