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Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair

Double strand breaks (DSBs) and interstrand crosslinks (ICLs) are toxic DNA lesions that can be repaired through multiple pathways, some of which involve shared proteins. One of these proteins, DNA Polymerase θ (Pol θ), coordinates a mutagenic DSB repair pathway named microhomology-mediated end join...

詳細記述

保存先:
書誌詳細
出版年:PLoS Genet
主要な著者: Beagan, Kelly, Armstrong, Robin L., Witsell, Alice, Roy, Upasana, Renedo, Nikolai, Baker, Amy E., Schärer, Orlando D., McVey, Mitch
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466332/
https://ncbi.nlm.nih.gov/pubmed/28542210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006813
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