Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair

Double strand breaks (DSBs) and interstrand crosslinks (ICLs) are toxic DNA lesions that can be repaired through multiple pathways, some of which involve shared proteins. One of these proteins, DNA Polymerase θ (Pol θ), coordinates a mutagenic DSB repair pathway named microhomology-mediated end join...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:PLoS Genet
Hauptverfasser: Beagan, Kelly, Armstrong, Robin L., Witsell, Alice, Roy, Upasana, Renedo, Nikolai, Baker, Amy E., Schärer, Orlando D., McVey, Mitch
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466332/
https://ncbi.nlm.nih.gov/pubmed/28542210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006813
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge