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Genomic Scars Generated by Polymerase Theta Reveal the Versatile Mechanism of Alternative End-Joining
For more than half a century, genotoxic agents have been used to induce mutations in the genome of model organisms to establish genotype-phenotype relationships. While inaccurate replication across damaged bases can explain the formation of single nucleotide variants, it remained unknown how DNA dam...
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| 發表在: | PLoS Genet |
|---|---|
| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Public Library of Science
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5068794/ https://ncbi.nlm.nih.gov/pubmed/27755535 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006368 |
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