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Mutational signatures of non‐homologous and polymerase theta‐mediated end‐joining in embryonic stem cells

Cells employ potentially mutagenic DNA repair mechanisms to avoid the detrimental effects of chromosome breaks on cell survival. While classical non‐homologous end‐joining (cNHEJ) is largely error‐free, alternative end‐joining pathways have been described that are intrinsically mutagenic. Which end‐...

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Détails bibliographiques
Publié dans:EMBO J
Auteurs principaux: Schimmel, Joost, Kool, Hanneke, van Schendel, Robin, Tijsterman, Marcel
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730883/
https://ncbi.nlm.nih.gov/pubmed/29079701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201796948
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