Translesion synthesis polymerases are dispensable for C. elegans reproduction but suppress genome scarring by polymerase theta-mediated end joining

Bases within DNA are frequently damaged, producing obstacles to efficient and accurate DNA replication by replicative polymerases. Translesion synthesis (TLS) polymerases, via their ability to catalyze nucleotide additions to growing DNA chains across DNA lesions, promote replication of damaged DNA,...

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Bibliographic Details
Published in:PLoS Genet
Main Authors: van Bostelen, Ivo, van Schendel, Robin, Romeijn, Ron, Tijsterman, Marcel
Format: Artigo
Language:Inglês
Published: Public Library of Science 2020
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7202663/
https://ncbi.nlm.nih.gov/pubmed/32330130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008759
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