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DNA polymerase θ specializes in incorporating synthetic expanded-size (xDNA) nucleotides
DNA polymerase θ (Polθ) is a unique A-family polymerase that is essential for alternative end-joining (alt-EJ) of double-strand breaks (DSBs) and performs translesion synthesis. Because Polθ is highly expressed in cancer cells, confers resistance to ionizing radiation and chemotherapy agents, and pr...
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| Опубликовано в: : | Nucleic Acids Res |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5100566/ https://ncbi.nlm.nih.gov/pubmed/27591252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw721 |
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