Biochemical Characterization of the Human Mitochondrial Replicative Twinkle Helicase: SUBSTRATE SPECIFICITY, DNA BRANCH MIGRATION, AND ABILITY TO OVERCOME BLOCKADES TO DNA UNWINDING

Mutations in the c10orf2 gene encoding the human mitochondrial DNA replicative helicase Twinkle are linked to several rare genetic diseases characterized by mitochondrial defects. In this study, we have examined the catalytic activity of Twinkle helicase on model replication fork and DNA repair stru...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Khan, Irfan, Crouch, Jack D., Bharti, Sanjay Kumar, Sommers, Joshua A., Carney, Sean M., Yakubovskaya, Elena, Garcia-Diaz, Miguel, Trakselis, Michael A., Brosh, Robert M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2016
Aiheet:
DNA and Chromosomes
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933186/
https://ncbi.nlm.nih.gov/pubmed/27226550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.712026
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia