Single-molecule DREEM imaging reveals DNA wrapping around human mitochondrial single-stranded DNA binding protein

Improper maintenance of the mitochondrial genome progressively disrupts cellular respiration and causes severe metabolic disorders commonly termed mitochondrial diseases. Mitochondrial single-stranded DNA binding protein (mtSSB) is an essential component of the mtDNA replication machinery. We utiliz...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Autores principales: Kaur, Parminder, Longley, Matthew J, Pan, Hai, Wang, Hong, Copeland, William C
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2018
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6265486/
https://ncbi.nlm.nih.gov/pubmed/30256971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky875
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