Single-molecule visualization of human BLM helicase as it acts upon double- and single-stranded DNA substrates

Bloom helicase (BLM) and its orthologs are essential for the maintenance of genome integrity. BLM defects represent the underlying cause of Bloom Syndrome, a rare genetic disorder that is marked by strong cancer predisposition. BLM deficient cells accumulate extensive chromosomal aberrations stemmin...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Xue, Chaoyou, Daley, James M, Xue, Xiaoyu, Steinfeld, Justin, Kwon, Youngho, Sung, Patrick, Greene, Eric C
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6868385/
https://ncbi.nlm.nih.gov/pubmed/31544923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz810
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