Single-molecule visualization of human BLM helicase as it acts upon double- and single-stranded DNA substrates

Bloom helicase (BLM) and its orthologs are essential for the maintenance of genome integrity. BLM defects represent the underlying cause of Bloom Syndrome, a rare genetic disorder that is marked by strong cancer predisposition. BLM deficient cells accumulate extensive chromosomal aberrations stemmin...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Xue, Chaoyou, Daley, James M, Xue, Xiaoyu, Steinfeld, Justin, Kwon, Youngho, Sung, Patrick, Greene, Eric C
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6868385/
https://ncbi.nlm.nih.gov/pubmed/31544923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz810
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