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Single-molecule visualization of human BLM helicase as it acts upon double- and single-stranded DNA substrates
Bloom helicase (BLM) and its orthologs are essential for the maintenance of genome integrity. BLM defects represent the underlying cause of Bloom Syndrome, a rare genetic disorder that is marked by strong cancer predisposition. BLM deficient cells accumulate extensive chromosomal aberrations stemmin...
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| Pubblicato in: | Nucleic Acids Res |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6868385/ https://ncbi.nlm.nih.gov/pubmed/31544923 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz810 |
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