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Single-molecule level structural dynamics of DNA unwinding by human mitochondrial Twinkle helicase

Knowledge of the molecular events in mitochondrial DNA (mtDNA) replication is crucial to understanding the origins of human disorders arising from mitochondrial dysfunction. Twinkle helicase is an essential component of mtDNA replication. Here, we employed atomic force microscopy imaging in air and...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Kaur, Parminder, Longley, Matthew J., Pan, Hai, Wang, Wendy, Countryman, Preston, Wang, Hong, Copeland, William C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7186178/
https://ncbi.nlm.nih.gov/pubmed/32213598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012795
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