A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses

Vaccine induction of broadly neutralizing antibodies (bnAbs) to human immunodeficiency virus (HIV) remains a major challenge. Germline-targeting immunogens hold promise for initiating the induction of certain bnAb classes; yet for most bnAbs, a strong dependence on antibody heavy chain complementari...

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Publié dans:Science
Auteurs principaux: Steichen, Jon M., Lin, Ying-Cing, Havenar-Daughton, Colin, Pecetta, Simone, Ozorowski, Gabriel, Willis, Jordan R., Toy, Laura, Sok, Devin, Liguori, Alessia, Kratochvil, Sven, Torres, Jonathan L., Kalyuzhniy, Oleksandr, Melzi, Eleonora, Kulp, Daniel W., Raemisch, Sebastian, Hu, Xiaozhen, Bernard, Steffen M., Georgeson, Erik, Phelps, Nicole, Adachi, Yumiko, Kubitz, Michael, Landais, Elise, Umotoy, Jeffrey, Robinson, Amanda, Briney, Bryan, Wilson, Ian A., Burton, Dennis R., Ward, Andrew B., Crotty, Shane, Batista, Facundo D., Schief, William R.
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7092357/
https://ncbi.nlm.nih.gov/pubmed/31672916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aax4380
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