Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens

How precursor frequencies and antigen affinities impact interclonal B cell competition is a particularly relevant issue for candidate germline-targeting HIV vaccine designs because of the in vivo rarity of naive B cells that recognize broadly neutralizing epitopes. Knowing the frequencies and affini...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Immunity
Main Authors: Abbott, Robert K., Lee, Jeong Hyun, Menis, Sergey, Skog, Patrick, Rossi, Meghan, Ota, Takayuki, Kulp, Daniel W., Bhullar, Deepika, Kalyuzhniy, Oleksandr, Havenar-Daughton, Colin, Schief, William R., Nemazee, David, Crotty, Shane
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5773359/
https://ncbi.nlm.nih.gov/pubmed/29287996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.11.023
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker