Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen

A major goal of HIV-1 vaccine research is the design of immunogens capable of inducing broadly neutralizing antibodies (bnAbs) that bind to the viral envelope glycoprotein (Env). Poor binding of Env to unmutated precursors of bnAbs, including those of the VRC01-class, appears to be a major problem f...

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Publicado en:Science
Main Authors: Jardine, Joseph G., Ota, Takayuki, Sok, Devin, Pauthner, Matthias, Kulp, Daniel W., Kalyuzhniy, Oleksandr, Skog, Patrick D., Thinnes, Theresa C., Bhullar, Deepika, Briney, Bryan, Menis, Sergey, Jones, Meaghan, Kubitz, Mike, Spencer, Skye, Adachi, Yumiko, Burton, Dennis R., Schief, William R., Nemazee, David
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669217/
https://ncbi.nlm.nih.gov/pubmed/26089355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aac5894
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