Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen

A major goal of HIV-1 vaccine research is the design of immunogens capable of inducing broadly neutralizing antibodies (bnAbs) that bind to the viral envelope glycoprotein (Env). Poor binding of Env to unmutated precursors of bnAbs, including those of the VRC01-class, appears to be a major problem f...

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Publicado no:Science
Main Authors: Jardine, Joseph G., Ota, Takayuki, Sok, Devin, Pauthner, Matthias, Kulp, Daniel W., Kalyuzhniy, Oleksandr, Skog, Patrick D., Thinnes, Theresa C., Bhullar, Deepika, Briney, Bryan, Menis, Sergey, Jones, Meaghan, Kubitz, Mike, Spencer, Skye, Adachi, Yumiko, Burton, Dennis R., Schief, William R., Nemazee, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669217/
https://ncbi.nlm.nih.gov/pubmed/26089355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aac5894
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