Rational HIV immunogen design to target specific germline B cell receptors

Vaccine development to induce broadly neutralizing antibodies (bNAbs) against HIV-1 is a global health priority. Potent VRC01-class bNAbs against the CD4 binding site of HIV gp120 have been isolated from HIV-1-infected individuals; however, such bNAbs have not been induced by vaccination. Wild-type...

Full description

Saved in:
Bibliographic Details
Main Authors: Jardine, Joseph, Julien, Jean-Philippe, Menis, Sergey, Ota, Takayuki, Kalyuzhniy, Oleksandr, McGuire, Andrew, Sok, Devin, Huang, Po-Ssu, MacPherson, Skye, Jones, Meaghan, Nieusma, Travis, Mathison, John, Baker, David, Ward, Andrew B., Burton, Dennis R., Stamatatos, Leonidas, Nemazee, David, Wilson, Ian A., Schief, William R.
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689846/
https://ncbi.nlm.nih.gov/pubmed/23539181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1234150
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items