Rational HIV immunogen design to target specific germline B cell receptors

Vaccine development to induce broadly neutralizing antibodies (bNAbs) against HIV-1 is a global health priority. Potent VRC01-class bNAbs against the CD4 binding site of HIV gp120 have been isolated from HIV-1-infected individuals; however, such bNAbs have not been induced by vaccination. Wild-type...

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Bibliographische Detailangaben
Hauptverfasser: Jardine, Joseph, Julien, Jean-Philippe, Menis, Sergey, Ota, Takayuki, Kalyuzhniy, Oleksandr, McGuire, Andrew, Sok, Devin, Huang, Po-Ssu, MacPherson, Skye, Jones, Meaghan, Nieusma, Travis, Mathison, John, Baker, David, Ward, Andrew B., Burton, Dennis R., Stamatatos, Leonidas, Nemazee, David, Wilson, Ian A., Schief, William R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689846/
https://ncbi.nlm.nih.gov/pubmed/23539181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1234150
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