A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses

Vaccine induction of broadly neutralizing antibodies (bnAbs) to human immunodeficiency virus (HIV) remains a major challenge. Germline-targeting immunogens hold promise for initiating the induction of certain bnAb classes; yet for most bnAbs, a strong dependence on antibody heavy chain complementari...

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Publicado no:Science
Main Authors: Steichen, Jon M., Lin, Ying-Cing, Havenar-Daughton, Colin, Pecetta, Simone, Ozorowski, Gabriel, Willis, Jordan R., Toy, Laura, Sok, Devin, Liguori, Alessia, Kratochvil, Sven, Torres, Jonathan L., Kalyuzhniy, Oleksandr, Melzi, Eleonora, Kulp, Daniel W., Raemisch, Sebastian, Hu, Xiaozhen, Bernard, Steffen M., Georgeson, Erik, Phelps, Nicole, Adachi, Yumiko, Kubitz, Michael, Landais, Elise, Umotoy, Jeffrey, Robinson, Amanda, Briney, Bryan, Wilson, Ian A., Burton, Dennis R., Ward, Andrew B., Crotty, Shane, Batista, Facundo D., Schief, William R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7092357/
https://ncbi.nlm.nih.gov/pubmed/31672916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aax4380
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