Negative allosteric modulators of the human calcium‐sensing receptor bind to overlapping and distinct sites within the 7‐transmembrane domain

BACKGROUND AND PURPOSE: Negative allosteric modulators (NAMs) that target the calcium‐sensing receptor (CaS receptor) were originally developed for the treatment of osteoporosis by stimulating the release of endogenous parathyroid hormone, but failed in human clinical trials. Several chemically and...

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Publicado en:Br J Pharmacol
Autores principales: Josephs, Tracy M., Keller, Andrew N., Khajehali, Elham, DeBono, Aaron, Langmead, Christopher J., Conigrave, Arthur D., Capuano, Ben, Kufareva, Irina, Gregory, Karen J., Leach, Katie
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7070164/
https://ncbi.nlm.nih.gov/pubmed/31881094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14961
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