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Negative allosteric modulators of the human calcium‐sensing receptor bind to overlapping and distinct sites within the 7‐transmembrane domain
BACKGROUND AND PURPOSE: Negative allosteric modulators (NAMs) that target the calcium‐sensing receptor (CaS receptor) were originally developed for the treatment of osteoporosis by stimulating the release of endogenous parathyroid hormone, but failed in human clinical trials. Several chemically and...
Enregistré dans:
| Publié dans: | Br J Pharmacol |
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| Auteurs principaux: | , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
John Wiley and Sons Inc.
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7070164/ https://ncbi.nlm.nih.gov/pubmed/31881094 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14961 |
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