Negative allosteric modulators of the human calcium‐sensing receptor bind to overlapping and distinct sites within the 7‐transmembrane domain

BACKGROUND AND PURPOSE: Negative allosteric modulators (NAMs) that target the calcium‐sensing receptor (CaS receptor) were originally developed for the treatment of osteoporosis by stimulating the release of endogenous parathyroid hormone, but failed in human clinical trials. Several chemically and...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Br J Pharmacol
Main Authors: Josephs, Tracy M., Keller, Andrew N., Khajehali, Elham, DeBono, Aaron, Langmead, Christopher J., Conigrave, Arthur D., Capuano, Ben, Kufareva, Irina, Gregory, Karen J., Leach, Katie
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Research Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7070164/
https://ncbi.nlm.nih.gov/pubmed/31881094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14961
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