Divergent effects of strontium and calcium‐sensing receptor positive allosteric modulators (calcimimetics) on human osteoclast activity

BACKGROUND AND PURPOSE: Strontium ranelate, a drug approved and until recently used for the treatment of osteoporosis, mediates its effects on bone at least in part via the calcium‐sensing (CaS) receptor. However, it is not known whether bone‐targeted CaS receptor positive allosteric modulators (PAM...

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Détails bibliographiques
Publié dans:Br J Pharmacol
Auteurs principaux: Diepenhorst, Natalie A, Leach, Katie, Keller, Andrew N, Rueda, Patricia, Cook, Anna E, Pierce, Tracie L, Nowell, Cameron, Pastoureau, Philippe, Sabatini, Massimo, Summers, Roger J, Charman, William N, Sexton, Patrick M, Christopoulos, Arthur, Langmead, Christopher J
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2018
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Themed Section: Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177624/
https://ncbi.nlm.nih.gov/pubmed/29714810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14344
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