Divergent effects of strontium and calcium‐sensing receptor positive allosteric modulators (calcimimetics) on human osteoclast activity

BACKGROUND AND PURPOSE: Strontium ranelate, a drug approved and until recently used for the treatment of osteoporosis, mediates its effects on bone at least in part via the calcium‐sensing (CaS) receptor. However, it is not known whether bone‐targeted CaS receptor positive allosteric modulators (PAM...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Diepenhorst, Natalie A, Leach, Katie, Keller, Andrew N, Rueda, Patricia, Cook, Anna E, Pierce, Tracie L, Nowell, Cameron, Pastoureau, Philippe, Sabatini, Massimo, Summers, Roger J, Charman, William N, Sexton, Patrick M, Christopoulos, Arthur, Langmead, Christopher J
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Themed Section: Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177624/
https://ncbi.nlm.nih.gov/pubmed/29714810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14344
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