Divergent effects of strontium and calcium‐sensing receptor positive allosteric modulators (calcimimetics) on human osteoclast activity

BACKGROUND AND PURPOSE: Strontium ranelate, a drug approved and until recently used for the treatment of osteoporosis, mediates its effects on bone at least in part via the calcium‐sensing (CaS) receptor. However, it is not known whether bone‐targeted CaS receptor positive allosteric modulators (PAM...

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Pubblicato in:Br J Pharmacol
Autori principali: Diepenhorst, Natalie A, Leach, Katie, Keller, Andrew N, Rueda, Patricia, Cook, Anna E, Pierce, Tracie L, Nowell, Cameron, Pastoureau, Philippe, Sabatini, Massimo, Summers, Roger J, Charman, William N, Sexton, Patrick M, Christopoulos, Arthur, Langmead, Christopher J
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
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Themed Section: Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177624/
https://ncbi.nlm.nih.gov/pubmed/29714810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14344
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