Identification of Global and Ligand-Specific Calcium Sensing Receptor Activation Mechanisms

Calcium sensing receptor (CaSR) positive allosteric modulators (PAMs) are therapeutically important. However, few are approved for clinical use, in part due to complexities in assessing allostery at a receptor where the endogenous agonist (extracellular calcium) is present in all biologic fluids. Su...

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Veröffentlicht in:Mol Pharmacol
Hauptverfasser: Keller, Andrew N., Kufareva, Irina, Josephs, Tracy M., Diao, Jiayin, Mai, Vyvyan T., Conigrave, Arthur D., Christopoulos, Arthur, Gregory, Karen J., Leach, Katie
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2018
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5941188/
https://ncbi.nlm.nih.gov/pubmed/29636377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.112086
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