Identification of Global and Ligand-Specific Calcium Sensing Receptor Activation Mechanisms

Calcium sensing receptor (CaSR) positive allosteric modulators (PAMs) are therapeutically important. However, few are approved for clinical use, in part due to complexities in assessing allostery at a receptor where the endogenous agonist (extracellular calcium) is present in all biologic fluids. Su...

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Detaylı Bibliyografya
Yayımlandı:Mol Pharmacol
Asıl Yazarlar: Keller, Andrew N., Kufareva, Irina, Josephs, Tracy M., Diao, Jiayin, Mai, Vyvyan T., Conigrave, Arthur D., Christopoulos, Arthur, Gregory, Karen J., Leach, Katie
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Pharmacology and Experimental Therapeutics 2018
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Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5941188/
https://ncbi.nlm.nih.gov/pubmed/29636377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.112086
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