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Engendering biased signalling from the calcium-sensing receptor for the pharmacotherapy of diverse disorders

The human calcium-sensing receptor (CaSR) is widely expressed in the body, where its activity is regulated by multiple orthosteric and endogenous allosteric ligands. Each ligand stabilizes a unique subset of conformational states, which enables the CaSR to couple to distinct intracellular signalling...

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Bibliografske podrobnosti
Main Authors: Leach, K, Sexton, P M, Christopoulos, A, Conigrave, A D
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Publishing Ltd 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3952794/
https://ncbi.nlm.nih.gov/pubmed/24111791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12420
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