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Engendering biased signalling from the calcium-sensing receptor for the pharmacotherapy of diverse disorders
The human calcium-sensing receptor (CaSR) is widely expressed in the body, where its activity is regulated by multiple orthosteric and endogenous allosteric ligands. Each ligand stabilizes a unique subset of conformational states, which enables the CaSR to couple to distinct intracellular signalling...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3952794/ https://ncbi.nlm.nih.gov/pubmed/24111791 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12420 |
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