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Biased signalling and proteinase-activated receptors (PARs): targeting inflammatory disease
Although it has been known since the 1960s that trypsin and chymotrypsin can mimic hormone action in tissues, it took until the 1990s to discover that serine proteinases can regulate cells by cleaving and activating a unique four-member family of GPCRs known as proteinase-activated receptors (PARs)....
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Blackwell Publishing Ltd
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3952797/ https://ncbi.nlm.nih.gov/pubmed/24354792 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12544 |
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